2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester - Names and Identifiers
Name | 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester
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Synonyms | Acotiamide-020 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-car... Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester 4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester(for Acotiamide) 4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester
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CAS | 877997-99-4
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EINECS | 300-102-8 |
2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester - Physico-chemical Properties
Molecular Formula | C14H14N2O6S
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Molar Mass | 338.34 |
Storage Condition | 2-8°C(protect from light) |
Physical and Chemical Properties | |
2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester - Introduction
Methyl 2-[(2-hydroxy-4, 5-dimethoxybenzoyl) amino]-1,3-thiazole-4-carboxylate is an organic compound whose chemical formula is C16H15N3O6S.
Nature:
-Appearance: White or off-white crystalline solid.
-Solubility: Soluble in chloroform, dichloromethane and dimethyl sulfoxide, slightly soluble in alcohol and ether, almost insoluble in water.
-Melting point: about 165-171°C.
Use:
-Pharmaceutical field: 2-[(2-hydroxy-4, 5-dimethoxybenzoyl) amino]-1,3-thiazole-4-carboxylic acid methyl ester is an effective anti-cancer drug, Can be used as an intermediate of anti-tumor drugs. It has the ability to inhibit DNA topoisomerase II and is able to inhibit the growth and spread of tumor cells.
-Scientific research laboratory: The compound can also be used in the synthesis of thiazole derivatives in chemical synthesis, as well as to study the growth and spread mechanism of tumor cells.
Preparation Method:
The preparation of 2-[(2-hydroxy-4, 5-dimethoxybenzoyl) amino]-1,3-thiazole -4-carboxylic acid methyl ester is generally carried out by multi-step reaction, with thiazole and p-hydroxyacetophenone as raw materials, the target product is obtained through reaction, protection, hydroxylation, substitution and other steps under appropriate conditions.
Safety Information:
-Pay attention to safety measures when using, wear protective gloves, protective glasses and protective clothing.
-Avoid inhalation, swallowing or contact with skin.
-In case of contact, flush the affected area immediately with plenty of water and bring the compound label when seeking medical attention.
-Storage should be kept away from fire, high temperature and oxidizing agents, and storage containers should be sealed, cool and dry.
Last Update:2024-04-09 02:00:49